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The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might end in an increase in methadone plasma concentrations, which could induce probably fatal respiratory melancholy. Additionally, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also lead to a r